General Information

  • ID:  hor004060
  • Uniprot ID:  P84369
  • Protein name:  Pyrokinin-4
  • Gene name:  NA
  • Organism:  Celatoblatta sp. (strain Blue Mountains) (Cockroach)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  Expressed in the brain, subesophageal ganglion and in the retrocerebral complex (mainly corpora cardiaca).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  unclassified Celatoblatta, Celatoblatta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DHMSHDVYSPRL
  • Length:  12(1-12)
  • Propeptide:  DHMSHDVYSPRL
  • Signal peptide:  NA
  • Modification:  T12 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004060_AF2.pdbhor004060_ESM.pdb

Physical Information

Mass: 165298 Formula: C62H93N19O20S
Absent amino acids: ACEFGIKNQTW Common amino acids: DHS
pI: 6.5 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -104.17 Boman Index: -3731
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 56.67
Instability Index: 6983.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  15626499
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.